恶性黑色素瘤的生存趋势：23年中显著改善。

Trends in survival from malignant melanoma: remarkable improvement in 23 years.

作者信息

Thörn M, Adami H O, Bergström R, Ringborg U, Krusemo U B

机构信息

Department of Surgery, University Hospital, Uppsala, Sweden.

出版信息

J Natl Cancer Inst. 1989 Apr 19;81(8):611-7. doi: 10.1093/jnci/81.8.611.

DOI:10.1093/jnci/81.8.611

PMID:2704050

Abstract

Trends in incidence of and mortality and survival from malignant melanoma in Sweden for 1960 through 1982 were analyzed. Incidence rates increased annually by 5.4% for females and by 5.8% for males, whereas mortality rates increased annually by 2.7% for females and 3.3% for males. For females, the 5-year relative survival (RS) rates increased by approximately 15 percentage points before 1970. In contrast, males before 1970 had a successive improvement in RS rates of 4.6-8.2 percentage points for each 5-year period of diagnosis. Multivariate analyses revealed that during the study period the malignant melanoma-specific hazard decreased by 71% [95% confidence interval (CI) = 59%-79%] for females and by 64% (95% CI = 54%-73%) for males during the first 5 years of follow-up.

摘要

分析了1960年至1982年瑞典恶性黑色素瘤的发病率、死亡率及生存率趋势。女性发病率每年增长5.4%，男性每年增长5.8%，而女性死亡率每年增长2.7%，男性每年增长3.3%。对于女性，1970年前5年相对生存率（RS）提高了约15个百分点。相比之下，1970年前男性在每5年诊断期内RS率连续提高4.6 - 8.2个百分点。多变量分析显示，在研究期间，随访的前5年女性恶性黑色素瘤特异性风险降低了71%[95%置信区间（CI）= 59% - 79%]，男性降低了64%（95% CI = 54% - 73%）。