Cengiz Fatma Pelin, Emiroglu Nazan, Su Ozlem, Onsun Nahide
Department of Dermatology, Bezmialem Vakif University Hospital, Bezmialem Vakif University, Istanbul, Turkey.
J Dermatol. 2016 Sep;43(9):1059-61. doi: 10.1111/1346-8138.13370. Epub 2016 Apr 4.
Plantar warts are one of the most common infectious skin disease caused by the human papillomavirus. In this study, cryotherapy with liquid nitrogen delivered by the physician, up to four treatments 2 weeks apart. Forty percent trichloroacetic acid (TCA) was applied to warts weekly up to four treatments. At the end of 4 weeks, the clinical improvement of the TCA group (n = 30) was six patients (20%) with no change, one patient (3.3%) with a mild response, 13 patients (43.3%) with a moderate response and 10 patients (33.3%) with a good response. In the cryotherapy group, clinical responses were 12 patients (40%) with no change, four patients (13.3%) with a mild response, 12 patients (40%) with a moderate response and two patients (6.7%) with a good response. There was a statistically significant difference in improvement between the two treatment groups (P = 0.027). According to our results, TCA 40% is more effective for clearance of plantar warts with significantly improved long-term safety profile.
跖疣是由人乳头瘤病毒引起的最常见的传染性皮肤病之一。在本研究中，由医生进行液氮冷冻治疗，每隔2周进行多达4次治疗。每周对疣体涂抹40%的三氯乙酸（TCA），多达4次治疗。在4周结束时，TCA组（n = 30）的临床改善情况为：6例患者（20%）无变化，1例患者（3.3%）有轻度反应，13例患者（43.3%）有中度反应，10例患者（33.3%）有良好反应。在冷冻治疗组中，临床反应为：12例患者（40%）无变化，4例患者（13.3%）有轻度反应，12例患者（40%）有中度反应，2例患者（6.7%）有良好反应。两个治疗组之间的改善情况存在统计学显著差异（P = 0.027）。根据我们的结果，40%的TCA对清除跖疣更有效，且长期安全性显著改善。
