Abdullah A N, Walzman M, Wade A
Department of Genitourinary Medicine, Coventry and Warwickshire Hospital, U.K.
Sex Transm Dis. 1993 Nov-Dec;20(6):344-5.
To evaluate and compare the efficacy and adverse effects of trichloracetic acid and cryotherapy (using liquid nitrogen) in the treatment of external genital warts.
Eighty-six patients were enrolled into a randomized clinical trial in the Genitourinary Medicine Department of the Coventry and Warwickshire Hospital (Coventry) between November 1990 and June 1991. External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis. They received up to six treatments of either therapy.
Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid. Thirty percent of patients who were treated with trichloracetic acid developed ulcerations at the site of its application.
In this study we found that cryotherapy (using liquid nitrogen) is more effective than that of trichloracetic acid for the treatment of external genital warts. It is also less likely to cause ulceration.
评估并比较三氯乙酸和冷冻疗法（使用液氮）治疗尖锐湿疣的疗效及不良反应。
1990年11月至1991年6月期间，86例患者纳入考文垂与沃里克郡医院（考文垂）泌尿生殖医学科的一项随机临床试验。尖锐湿疣患者每周接受一次三氯乙酸或冷冻疗法（使用液氮）治疗，两种疗法均最多接受6次治疗。
接受最多6次冷冻治疗的患者中，86%的病例疣体完全清除；接受最多6次三氯乙酸治疗的患者中，70%的病例疣体完全清除。接受三氯乙酸治疗的患者中有30%在用药部位出现溃疡。
在本研究中，我们发现冷冻疗法（使用液氮）治疗尖锐湿疣比三氯乙酸更有效，且引起溃疡的可能性更小。
