Bu P
Ping Bu, Department of Gastroenterology, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China.
World J Gastroenterol. 1997 Jun 15;3(2):129-30. doi: 10.3748/wjg.v3.i2.129.
To study the action of remedies for enhancing resistance and relieving blood stasis on metastasis in postoperative gastric cancer and its influence on ornithine decarboxylase (ODC).
Sixty-three postoperative patients with gastric cancer were randomly divided into two groups. Thirty-one patients were treated with western medicine consisting of the FAP (5-fluorouracil, adriamycin, cisplatin) and CODP regimens (cyclophosphamide, vincristine, daunorubicin, prednisone), whereas 32 patients were treated with the FAP regimen and traditional Chinese medicine. Correlations were made between the ODC levels detected before and after treatment and other factors such as tumor diameter, infiltration depth, histological type, and lymph node metastasis.
The ODC levels in the gastric cancer tissue and adjacent normal gastric mucosal tissue were significantly higher in the patients than in the controls. There was an obvious correlation between increased ODC and tumor size, infiltration depth, degree of differentiation, and lymph node metastasis. Six months later, there were no significant changes in the ODC levels of the group using only Western medicine, while the ODC levels decreased markedly in the group using combined Western and traditional Chinese medicine (P < 0.01).
The effects of traditional Chinese medicine remedies on metastases in postoperative gastric cancer are related to the reduction of ODC activity.
研究扶正化瘀法对胃癌术后转移的作用及其对鸟氨酸脱羧酶（ODC）的影响。
将63例胃癌术后患者随机分为两组。31例患者采用由FAP（氟尿嘧啶、阿霉素、顺铂）和CODP方案（环磷酰胺、长春新碱、柔红霉素、泼尼松）组成的西医治疗，而32例患者采用FAP方案加中药治疗。对治疗前后检测的ODC水平与肿瘤直径、浸润深度、组织学类型和淋巴结转移等其他因素进行相关性分析。
患者胃癌组织和癌旁正常胃黏膜组织中的ODC水平明显高于对照组。ODC升高与肿瘤大小、浸润深度、分化程度和淋巴结转移之间存在明显相关性。6个月后，单纯使用西医治疗组的ODC水平无明显变化，而中西医结合治疗组的ODC水平明显下降（P<0.01）。
中药对胃癌术后转移的作用与降低ODC活性有关。
