Nakanishi I, Sowa M, Otani S
First Department of Surgery, Osaka City University Medical School, Japan.
Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):569-72.
Ornithine decarboxylase (ODC) activity and polyamine levels in mucosal specimens obtained by endoscopic biopsy from the stomal portion and greater curvature of the gastric remnant mucosa taken from 181 patients were determined and compared with the histopathological findings. The results obtained can be summarized as follows. (a) The ODC activity was significantly higher in the stomal portion [455 +/- 340 (mean +/- SD)] of the gastric remnant than in the greater curvature (148 +/- 107). The ODC activity of the stomal portion was significantly higher following a Billroth's II method (599 +/- 417) than following any other operative method that consists of a Billroth's I method (327 +/- 172) and a Roux-en Y (341 +/- 191). (b) The levels of total polyamine, putrescine, spermidine, and spermine were also significantly higher in the stomal portion of the gastric remnant than in the greater curvature. There were no significant differences in the stomal tissue level of any of these substances among operative procedures used. (c) Histopathological changes consisting of glandular dilatation and an irregular glandular structure were detected more frequently in the stomal mucosal specimens, especially following a Billroth's II method. In summary, the present findings suggest that the measurement of ODC activity may thus be considered as one method of estimating the risk of carcinogenesis.
对181例患者胃残余黏膜吻合口部和大弯侧内镜活检获取的黏膜标本中的鸟氨酸脱羧酶（ODC）活性和多胺水平进行了测定，并与组织病理学结果进行比较。所得结果总结如下：（a）胃残余吻合口部的ODC活性[455±340（均值±标准差）]显著高于大弯侧（148±107）。毕Ⅱ式手术后吻合口部的ODC活性（599±417）显著高于毕Ⅰ式手术（327±172）和Roux-en Y手术（341±191）后的活性。（b）胃残余吻合口部的总多胺、腐胺、亚精胺和精胺水平也显著高于大弯侧。所用手术方式之间这些物质在吻合口组织中的水平无显著差异。（c）在吻合口黏膜标本中，尤其是毕Ⅱ式手术后，更频繁地检测到由腺体扩张和不规则腺体结构组成的组织病理学变化。总之，目前的研究结果表明，ODC活性的测定可被视为评估致癌风险的一种方法。
