Chen Hsin-Yi, Liu Chin-Chih, Chen Ruey-Hwa
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan ; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.
Cell Div. 2016 Apr 1;11:5. doi: 10.1186/s13008-016-0017-2. eCollection 2016.
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. KLHL20 is a substrate-binding subunit of Cullin3 (Cul3) ubiquitin ligase. Recent studies have identified a number of substrates of KLHL20-based ubiquitin ligase. Through ubiquitination of these substrates, KLHL20 elicits diverse cellular functions, some of which are associated with human diseases. Furthermore, the functions, subcellular localizations, and expression of KLHL20 are regulated by several physiological and stressed signals, which allow KLHL20 to preferentially act on certain substrates to response to these signals. Here, we provide a summary of the functions and regulations of KLHL20 in several physiological processes and stress responses and its disease implications.
Cullin-RING泛素连接酶是真核生物中最大的泛素连接酶家族，属于多蛋白复合物。在这些复合物中，Cullin蛋白作为支架连接连接酶的两个功能模块，即催化亚基和底物结合亚基。KLHL20是Cullin3（Cul3）泛素连接酶的底物结合亚基。最近的研究已经鉴定出许多基于KLHL20的泛素连接酶的底物。通过对这些底物进行泛素化，KLHL20引发多种细胞功能，其中一些与人类疾病相关。此外，KLHL20的功能、亚细胞定位和表达受多种生理和应激信号调控，这使得KLHL20能够优先作用于某些底物以响应这些信号。在此，我们总结了KLHL20在几种生理过程和应激反应中的功能、调控及其对疾病的影响。
