Wu Junxiang, Huang Jing, Long Fengxiang, Wang Chengkai, Wu Zhangwen, Gou Chengjun
1 Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, Sichuan, China.
2 College of Chemistry, Sichuan University, Chengdu, Sichuan, China.
Br J Radiol. 2016 Jun;89(1062):20150783. doi: 10.1259/bjr.20150783. Epub 2016 Apr 4.
Recently, a new catheter-based (32)P brachytherapy source has been developed (College of Chemistry, Sichuan University) for use in high-dose-rate afterloader. This study presents the results of the dosimetric data of the Geant4 Monte Carlo (MC) simulation toolkit for this new (32)P brachytherapy source.
The new (32)P source had dimensions of 0.50-cm length and 0.08-cm diameter and was encapsulated in teflon. In this study, we attempted to obtain dosimetric data for this new source, as required by the formalism proposed by the American Association of Physicists in Medicine reports TG60 and TG149. The source was located in a 30-cm radius theoretical sphere water phantom, and the absorbed dose of the source was calculated using MC code.
The dosimetric data included the reference absorbed dose rate, the radial dose function in the range of 0.10-0.50 cm at a longitudinal axis, the polynomial function for the radial dose function and the anisotropy function with a θ value of 0-90° in 5° intervals and an r of 0.10-0.35 cm in 0.01-cm intervals. The radial and axial dose profiles and away-along quality assurance table are also calculated for the unsheathed (32)P source. The dose rate D(r0,θ0) at the reference point for the unsheathed (32)P source is determined to be equal to 1.2660 ± 0.0006 cGy s(-1) mCi. The radial dose function of the new (32)P source shows good agreement with the other (32)P source presented in this work with an average difference of 1.78%.
Dosimetric data are provided for the new (32)P source. These data could be used in treatment-planning systems in clinical practice.
Provided a new beta-emitting brachytherapy source that is intended for treatment of liver cancer. A dosimetric study of the unsheathed (32)P source for which no published dosimetric data existed was performed.
最近，四川大学化学学院研发了一种新型基于导管的（32）P近距离放射治疗源，用于高剂量率后装治疗机。本研究展示了使用Geant4蒙特卡罗（MC）模拟工具包对这种新型（32）P近距离放射治疗源进行剂量学数据模拟的结果。
新型（32）P源长度为0.50厘米，直径为0.08厘米，封装在聚四氟乙烯中。在本研究中，我们试图按照美国医学物理师协会报告TG60和TG149中提出的形式要求，获取该新型源的剂量学数据。该源位于半径为30厘米的理论球形水体模中，使用MC代码计算源的吸收剂量。
剂量学数据包括参考吸收剂量率、纵轴上0.10 - 0.50厘米范围内的径向剂量函数、径向剂量函数的多项式函数以及θ值在0 - 90°以5°间隔、r在0.10 - 0.35厘米以0.01厘米间隔的各向异性函数。还计算了无护套（32）P源的径向和轴向剂量分布以及离轴质量保证表。无护套（32）P源在参考点的剂量率D（r0，θ0）确定为等于1.2660 ± 0.0006 厘戈瑞·秒（-1）·毫居里。新型（32）P源的径向剂量函数与本研究中展示的其他（32）P源显示出良好的一致性，平均差异为1.78%。
提供了新型（32）P源的剂量学数据。这些数据可用于临床实践中的治疗计划系统。
提供了一种用于治疗肝癌的新型β发射近距离放射治疗源。对尚无已发表剂量学数据的无护套（32）P源进行了剂量学研究。
