Hsiung Hui-Yin, Fann Jean Ching-Yuan, Yen Amy Ming-Fang, Chen Sam Li-Sheng, Chiu Sherry Yueh-Hsia, Ku Tsung-Ho, Liu Tzeng-Ying, Chen Hsiu-Hsi, Lin Ming-Wei
a Institute of Public Health, National Yang-Ming University , Taipei , Taiwan.
b Department of Health Industry Management , School of Healthcare Management, Kainan University , Tao-Yuan , Taiwan.
Nutr Cancer. 2016 May-Jun;68(4):598-610. doi: 10.1080/01635581.2016.1156712. Epub 2016 Apr 4.
We assessed how individual dietary intakes act at different points in the chain of sequential stage of the Correa model in an area of Taiwan with high incidence of gastric cancer (GC). Using data on 2,201 participants in a two-stage screening for gastric neoplasia with pepsinogen test, we identified 154 superficial gastritis (SG), 32 atrophic gastritis (AG), 117 intestinal metaplasia (IM), and 22 GC. Effects of individual item-based and construct-based dietary variables aggregated by factor analysis on each stage of gastric neoplasm were assessed. Based on 1,211 subjects with complete information on serological test and dietary questionnaire, SG was associated with positive quartile trend for the intake of meat (trend test P = 0.0014) and the intake of fruits and leafy vegetables (trend test P = 0.0177), but with the negative trend for the intake of shrimp sauce (trend test P = 0.039). A significant positive association was noted between milk and AG (trend test P = 0.014) and IM (P = 0.0087). A positive association between seafood and IM was noted (P = 0.011). Frequent leafy vegetable intake based on individual item was inversely associated with GC (P = 0.0084), whereas frequent intake of meat showed a high positive association (P<0.001). Stage-specific dietary factors underpinning the Correa model were identified.
我们评估了在台湾胃癌（GC）高发地区，个体饮食摄入量如何在科雷亚模型连续阶段的不同环节发挥作用。利用2201名参与者进行胃肿瘤两阶段胃蛋白酶原检测筛查的数据，我们确定了154例浅表性胃炎（SG）、32例萎缩性胃炎（AG）、117例肠化生（IM）和22例胃癌。评估了通过因子分析汇总的基于个体项目和基于结构的饮食变量对胃肿瘤各阶段的影响。基于1211名血清学检测和饮食问卷信息完整的受试者，SG与肉类摄入量（趋势检验P = 0.0014）、水果和叶菜类蔬菜摄入量（趋势检验P = 0.0177）的四分位数正趋势相关，但与虾酱摄入量的负趋势相关（趋势检验P = 0.039）。牛奶与AG（趋势检验P = 0.014）和IM（P = 0.0087）之间存在显著正相关。海鲜与IM之间存在正相关（P = 0.011）。基于个体项目的频繁叶菜类蔬菜摄入与GC呈负相关（P = 0.0084），而频繁摄入肉类则呈高度正相关（P<0.001）。确定了支持科雷亚模型的特定阶段饮食因素。
