Zhao Zhanwei, Yin Zifang, Zhao Qingchuan
Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.
Department of Obstetrics, Northwestern Women and Children's Hospital, Shaanxi, China.
Oncotarget. 2017 May 2;8(18):30563-30575. doi: 10.18632/oncotarget.15699.
The associations between red and processed meat consumption and gastric cancer risk have remained inconclusive. We performed a systematic review and meta-analysis to analyze these associations. We searched PubMed and EMBASE to identify studies published from inception through October 2016. Subtype analyses of gastric cancer (gastric cardia adenocarcinoma and gastric non-cardiac adenocarcinoma) and dose-response analyses were performed. We finally selected 42 eligible studies. The summary relative risks of highest versus lowest consumption were positive for case-control studies with 1.67 (1.36-2.05) for red meat and 1.76 (1.51-2.05) for processed meat, but negative for cohort studies with 1.14 (0.97-1.34) for red meat and 1.23 (0.98-1.55) for processed meat. Subtype analyses of cohort studies suggested null results for gastric cardia adenocarcinoma (red meat, P = 0.79; processed meat, P = 0.89) and gastric non-cardiac adenocarcinoma (red meat, P = 0.12; processed meat, P = 0.12). In conclusion, the present analysis suggested null results between red and processed meat consumption and gastric cancer risk in cohort studies, although case-control studies yielded positive associations. Further well-designed prospective studies are needed to validate these findings.
红肉及加工肉类的摄入量与胃癌风险之间的关联尚无定论。我们进行了一项系统综述和荟萃分析来剖析这些关联。我们检索了PubMed和EMBASE，以识别从起始至2016年10月发表的研究。对胃癌（贲门腺癌和非贲门腺癌）进行了亚型分析，并开展了剂量反应分析。我们最终纳入了42项符合条件的研究。在病例对照研究中，红肉摄入量最高组与最低组相比的汇总相对风险为阳性，红肉为1.67（1.36 - 2.05），加工肉类为1.76（1.51 - 2.05）；但在队列研究中为阴性，红肉为1.14（0.97 - 1.34），加工肉类为1.23（0.98 - 1.55）。队列研究的亚型分析表明，贲门腺癌（红肉，P = 0.79；加工肉类，P = 0.89）和非贲门腺癌（红肉，P = 0.12；加工肉类，P = 0.12）的结果均为无效。总之，本分析表明，在队列研究中，红肉及加工肉类的摄入量与胃癌风险之间结果无效，尽管病例对照研究显示存在正相关。需要进一步开展设计良好的前瞻性研究来验证这些发现。
