肌肉骨骼癌中的骨形态发生蛋白信号传导
Bone morphogenetic protein signaling in musculoskeletal cancer.
作者信息
Bami Myrto, Mavrogenis Andreas F, Angelini Andrea, Milonaki Mandy, Mitsiokapa Evanthia, Stamoulis Dimitrios, Soucacos Panayotis N
机构信息
Orthopaedic Research and Education Center, "Panayotis N. Soucacos", Athens University Medical School, Attikon University Hospital, Athens, Greece.
First Department of Orthopaedics, Athens University Medical School, Attikon University Hospital, Athens, Greece.
出版信息
J Cancer Res Clin Oncol. 2016 Oct;142(10):2061-72. doi: 10.1007/s00432-016-2149-9. Epub 2016 Apr 4.
PURPOSE
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) superfamily of proteins; they were initially named after their ability to induce ectopic bone formation. Published studies have proved BMPs' role in a variety of biological processes such as embryogenesis and patterning of body axes, and maintaining adult tissue homeostasis. Other studies have focused on BMPs properties, functions and possible involvement in skeletal diseases, including cancer.
METHODS
A literature search mainly paying attention to the role of BMPs in musculoskeletal tumors was performed in electronic databases.
RESULTS
This article discusses BMPs synthesis and signaling, and summarizes their prominent roles in the skeletal system for the differentiation of osteoblasts, osteocytes and chondrocytes.
CONCLUSIONS
The review emphasizes on the role of BMP signaling in the initiation and progression of musculoskeletal cancer.
目的
骨形态发生蛋白（BMPs）属于转化生长因子-β（TGF-β）超家族蛋白；它们最初因其诱导异位骨形成的能力而得名。已发表的研究证明BMPs在多种生物学过程中发挥作用，如胚胎发育和体轴模式形成，以及维持成体组织稳态。其他研究则聚焦于BMPs的特性、功能以及可能参与包括癌症在内的骨骼疾病。
方法
在电子数据库中进行文献检索，主要关注BMPs在肌肉骨骼肿瘤中的作用。
结果
本文讨论了BMPs的合成和信号传导，并总结了它们在骨骼系统中对成骨细胞、骨细胞和软骨细胞分化的突出作用。
结论
本综述强调了BMP信号传导在肌肉骨骼癌症发生和发展中的作用。
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