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Aspirin may improve outcome in sepsis by augmentation of the inflammatory response.

作者信息

Kiers H D, Kox M, van der Heijden W A, Riksen N P, Pickkers P

机构信息

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

出版信息

Intensive Care Med. 2016 Jun;42(6):1096. doi: 10.1007/s00134-016-4264-0. Epub 2016 Apr 4.

DOI:10.1007/s00134-016-4264-0
PMID:27043236
Abstract
摘要

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Aspirin may improve outcome in sepsis by augmentation of the inflammatory response.阿司匹林可能通过增强炎症反应来改善脓毒症的预后。
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Augmentation of U46619 induced human platelet aggregation by aspirin.阿司匹林增强U46619诱导的人血小板聚集。
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Platelet aggregation in response to collagen and thrombin reliably detects the ingestion of low-dose aspirin.血小板对胶原蛋白和凝血酶的聚集反应能够可靠地检测低剂量阿司匹林的摄入情况。
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Antiplatelet effects of angiotensin-converting enzyme inhibitors compared with aspirin and clopidogrel: a pilot study with whole-blood aggregometry.血管紧张素转换酶抑制剂与阿司匹林和氯吡格雷的抗血小板作用比较：一项全血凝集试验的初步研究
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The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease.阿司匹林的抗血小板作用在冠心病患者中会被质子泵抑制剂所减弱。
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Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study.阿司匹林治疗与危重症患者预后的关联：一项巢式队列研究。
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引用本文的文献

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Aspirin is associated with improved 30-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study based on MIMIC IV database.阿司匹林与脓毒症相关性肝损伤患者30天死亡率的改善相关：一项基于MIMIC IV数据库的回顾性队列研究。
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Aspirin use is associated with the reduced mortality risk in chronic obstructive pulmonary disease with sepsis: a retrospective study using the MIMIC-IV database.阿司匹林的使用与慢性阻塞性肺疾病合并脓毒症患者死亡率降低相关：一项使用MIMIC-IV数据库的回顾性研究
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本文引用的文献

1
Septic shock from community-onset pneumonia: is there a role for aspirin plus macrolides combination?社区获得性肺炎所致感染性休克：阿司匹林联合大环内酯类药物是否有效？
Intensive Care Med. 2016 Feb;42(2):301-2. doi: 10.1007/s00134-015-4139-9. Epub 2015 Nov 19.
2
Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?免疫疗法辅助治疗脓毒症：从免疫抑制到免疫刺激。是否需要改变范式？
Am J Respir Crit Care Med. 2013 Jun 15;187(12):1287-93. doi: 10.1164/rccm.201301-0036CP.
3
Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?
Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS.
阿司匹林与必需脂肪酸联合使用在预防或改善脓毒症或急性呼吸窘迫综合征方面优于单独使用阿司匹林。
Lipids Health Dis. 2016 Nov 25;15(1):206. doi: 10.1186/s12944-016-0377-2.
4
Role of aspirin in patients with septic shock: a complex and intriguing relationship.阿司匹林在感染性休克患者中的作用：一种复杂而有趣的关系。
Intensive Care Med. 2016 Jun;42(6):1097. doi: 10.1007/s00134-016-4300-0. Epub 2016 Mar 31.
促炎细胞因子与脓毒症综合征：是量不足，还是过犹不及？
Trends Immunol. 2003 May;24(5):254-8. doi: 10.1016/s1471-4906(03)00079-6.
4
A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures.短期口服阿司匹林可增加全血培养物中白细胞介素-18诱导的γ干扰素生成。
Eur Cytokine Netw. 2000 Sep;11(3):379-82.
5
Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.前列腺素E2调节巨噬细胞衍生的肿瘤坏死因子基因表达。
J Biol Chem. 1988 Apr 15;263(11):5380-4.
6
Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.静脉注射内毒素后正常人体内白细胞介素8和肿瘤坏死因子的检测：抗炎药物的作用
J Exp Med. 1991 Apr 1;173(4):1021-4. doi: 10.1084/jem.173.4.1021.