立体选择性全合成生物活性海洋天然产物 Biselyngbyolide B。
Stereoselective Total Synthesis of Bioactive Marine Natural Product Biselyngbyolide B.
机构信息
Department of Organic Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata-700032, India.
出版信息
Org Lett. 2016 Apr 15;18(8):1908-11. doi: 10.1021/acs.orglett.6b00713. Epub 2016 Apr 4.
PMID:27043308
Abstract
A convergent strategy for the stereoselective total synthesis of biologically active marine natural product biselyngbyolide B has been developed. Key strategies of this synthesis include Jamison protocol of trans-hydroalumination/allylation for installation of C18-C23 olefin moiety and intramolecular Heck coupling for macrocyclization.
摘要
已开发出一种用于生物活性海洋天然产物双表愈创内酯 B 的对映选择性全合成的会聚策略。该合成的关键策略包括用于安装 C18-C23 烯烃部分的 Jamison 反式氢铝化/烯丙基化协议和用于大环化的分子内 Heck 偶联。
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