Portin Petter
Duodecim. 2016;132(1):26-32.
Gene therapy is divided into somatic and germ line therapy. The latter involves reproductive cells or their stem cells, and its results are heritable. The effects of somatic gene therapy are generally restricted to a single tissue of the patient in question. Until now, all gene therapies in the world have belonged to the regime of somatic therapy, germ line therapy having been a theoretical possibility only. Very recently, however, a method has been developed which is applicable to germ line therapy as well. In addition to technical challenges, severe ethical problems are associated with germ line therapy, demanding opinion statement.
基因治疗分为体细胞治疗和生殖系治疗。后者涉及生殖细胞或其干细胞,其结果是可遗传的。体细胞基因治疗的效果通常仅限于所讨论患者的单个组织。到目前为止,世界上所有的基因治疗都属于体细胞治疗范畴,生殖系治疗仅仅是一种理论上的可能性。然而,最近已开发出一种也适用于生殖系治疗的方法。除了技术挑战外,生殖系治疗还存在严重的伦理问题,需要发表意见声明。