Edwards Hannah B, Savović Jelena, Whiting Penny, Leach Verity, Richards Alison, Cullum Sarah, Cheston Richard
School of Social and Community Medicine, University of Bristol and National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) West, Bristol, UK.
School of Social and Community Medicine, University of Bristol, Bristol, UK.
BMJ Open. 2016 Apr 4;6(4):e010835. doi: 10.1136/bmjopen-2015-010835.
Serious adverse outcomes for people with dementia include institutionalisation, hospitalisation, death, development of behavioural and psychiatric symptoms, and reduced quality of life. The quality of the relationship between the person with dementia and their informal/family carer is thought to affect the risk of these outcomes. However, little is known about which aspects of relationship quality are important, or how they affect outcomes for people with dementia.
This will be a systematic review of the literature. Electronic databases MEDLINE, EMBASE, Web of Science, PsycInfo, the Cochrane Database, ALOIS and OpenGrey will be searched from inception. 2 independent reviewers will screen results for eligibility with standardised criteria. Data will be extracted for relevant studies, and information on the associations between relationship quality and dementia outcomes will be synthesised. Meta-analysis will be performed if possible to calculate pooled effect sizes. Narrative synthesis will be performed if study heterogeneity rules out meta-analysis.
Ethical review is not necessary as this review summarises data from previous studies. Results will be disseminated via peer-reviewed publication. Results will also be disseminated to a patient and public involvement group and an expert panel for their views on the findings and implications for future work.
CRD42015020518.
痴呆症患者的严重不良后果包括被送进养老院、住院、死亡、出现行为和精神症状以及生活质量下降。人们认为痴呆症患者与其非正式/家庭护理者之间关系的质量会影响这些后果的风险。然而，对于关系质量的哪些方面很重要，或者它们如何影响痴呆症患者的后果，我们知之甚少。
这将是一项对文献的系统综述。将从起始点开始检索电子数据库MEDLINE、EMBASE、科学引文索引、心理学文摘数据库、考克兰系统评价数据库、老年护理与健康信息系统（ALOIS）和OpenGrey。两名独立的评审员将使用标准化标准筛选结果以确定其是否符合条件。将提取相关研究的数据，并综合有关关系质量与痴呆症后果之间关联的信息。如果可能，将进行荟萃分析以计算合并效应量。如果研究异质性排除了荟萃分析，则将进行叙述性综合分析。
由于本综述总结了先前研究的数据，因此无需进行伦理审查。结果将通过同行评审出版物进行传播。结果还将传播给患者和公众参与小组以及专家小组，以听取他们对研究结果及其对未来工作影响的意见。
CRD42015020518。
