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足踝骨折门诊创伤患者的血栓预防:使用风险评分系统的前瞻性研究

Thromboprophylaxis in Ambulatory Trauma Patients With Foot and Ankle Fractures: Prospective Study Using a Risk Scoring System.

作者信息

Haque Syed, Bishnoi Amit, Khairandish Hamidreza, Menon Dipen

机构信息

Kettering General Hospital, Kettering, UK

Kettering General Hospital, Kettering, UK.

出版信息

Foot Ankle Spec. 2016 Oct;9(5):388-93. doi: 10.1177/1938640016640892. Epub 2016 Apr 4.

Abstract

UNLABELLED

Lower-limb immobilization has been implicated as an etiological factor for venous thromboembolic events (VTEs). However, there is no patient-centered scoring system available for risk assessment in ambulatory trauma patients with temporary lower-limb immobilization. A patient questionnaire scoring system has been developed for ambulatory patients with foot and ankle fracture being managed nonoperatively as outpatients by temporary lower-limb immobilization. Patients are classed as either high or low risk for developing a VTE and offered low-molecular-weight heparin (LMWH) accordingly. This is a prospective study of 150 patients with a follow-up of 6 months. Only 3 patients developed VTEs: one was noncompliant with medicine, one was started on LMWH 2 days after getting a plaster cast, and the third was not started on LMWH in spite of family history of VTEs. This study showed that using this scoring system, LMWH can be used safely and effectively as a thromboprophylactic agent for ambulatory trauma patients requiring temporary lower-limb immobilization to manage foot and ankle fractures. It is a step toward developing a validated clinical prediction score to enable risk assessment in ambulatory trauma patients who are managed non-operatively with temporary lower limb immobilization.

LEVELS OF EVIDENCE

Prognostic, Level IV: Case series.

摘要

未标注

下肢固定被认为是静脉血栓栓塞事件(VTE)的一个病因。然而,对于门诊创伤患者因下肢临时固定而进行风险评估,尚无以患者为中心的评分系统。已开发出一种患者问卷评分系统,用于对因足部和踝关节骨折而门诊非手术治疗并临时下肢固定的患者进行评估。患者被分为发生VTE的高风险或低风险,并据此给予低分子量肝素(LMWH)。这是一项对150例患者进行的前瞻性研究,随访6个月。仅3例患者发生VTE:1例未遵医嘱服药,1例在打石膏2天后开始使用LMWH,第3例尽管有VTE家族史但未开始使用LMWH。本研究表明,使用该评分系统,LMWH可作为预防性血栓形成药物安全有效地用于需要临时下肢固定以治疗足部和踝关节骨折的门诊创伤患者。这是朝着开发一个经过验证的临床预测评分迈出的一步,以便能够对通过临时下肢固定进行非手术治疗的门诊创伤患者进行风险评估。

证据水平

预后性,IV级:病例系列。

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