Amdur H S, Levin R E
Thames Gynecologic Group, New London, Connecticut.
Obstet Gynecol. 1989 May;73(5 Pt 2):843-7.
The first reported case of eosinophilic fasciitis developing in pregnancy is discussed, and the obstetric management is reported. Eosinophilic fasciitis is a rare disease characterized by pain, swelling, and tenderness over the extremities, followed by induration of the skin. Laboratory findings include peripheral eosinophilia, hypergammaglobulinemia, an elevated erythrocyte sedimentation rate, distinctive histopathologic changes, and scleroderma-like skin induration without rheumatoid serologic markers. Diagnosis is made by biopsy of the deep fascia of the affected area. The deep fascia will be infiltrated with plasma cells, lymphocytes, and eosinophils. Prednisone is the therapy of choice. Carpal tunnel syndrome and rare serious hematologic abnormalities have been associated with eosinophilic fasciitis.
本文讨论了首例妊娠期发生嗜酸性筋膜炎的病例报告，并报告了产科处理情况。嗜酸性筋膜炎是一种罕见疾病，其特征为四肢疼痛、肿胀和压痛，随后皮肤出现硬结。实验室检查结果包括外周血嗜酸性粒细胞增多、高球蛋白血症、红细胞沉降率升高、独特的组织病理学改变以及无类风湿血清学标志物的硬皮病样皮肤硬结。通过对受累区域深筋膜进行活检来做出诊断。深筋膜会有浆细胞、淋巴细胞和嗜酸性粒细胞浸润。泼尼松是首选治疗药物。腕管综合征和罕见的严重血液学异常与嗜酸性筋膜炎有关。
