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伪装成肝母细胞瘤的胰腺母细胞瘤:诊断难题。

Pancreatoblastoma masquerading as hepatoblastoma: A diagnostic dilemma.

作者信息

Prabhu Aruna, Bhagat Monica, Ramadwar Mukta, Qureshi Sajid S

机构信息

Department of Pediatric Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

出版信息

J Indian Assoc Pediatr Surg. 2016 Apr-Jun;21(2):84-6. doi: 10.4103/0971-9261.176969.

DOI:10.4103/0971-9261.176969
PMID:27046982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4790136/
Abstract

Clinicoradiological and histopathological differentiation of pancreatoblastoma from hepatoblastoma can often be a challenge in clinical practice owing to their peculiar resemblance. We report a case of a 4-year-old boy with a right hypochondriac region mass, which was diagnosed as hepatoblastoma on the basis of imaging, raised tumor marker, and biopsy; however, pancreatic origin of the mass was ascertained on exploration and pancreatoblastoma was confirmed on histopathology.

摘要

在临床实践中,由于胰腺母细胞瘤和成肝细胞瘤外观极为相似,二者在临床放射学及组织病理学上的鉴别诊断往往颇具挑战。我们报告一例4岁男性患儿,其右季肋区有一肿块,根据影像学检查、肿瘤标志物升高及活检结果诊断为成肝细胞瘤;然而,术中探查确定肿块起源于胰腺,组织病理学检查确诊为胰腺母细胞瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e894/4790136/1f729981a05c/JIAPS-21-84-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e894/4790136/6703b755e1be/JIAPS-21-84-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e894/4790136/1f729981a05c/JIAPS-21-84-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e894/4790136/6703b755e1be/JIAPS-21-84-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e894/4790136/1f729981a05c/JIAPS-21-84-g002.jpg

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本文引用的文献

1
Pancreatic tumors in children and adolescents: the Italian TREP project experience.儿童和青少年胰腺肿瘤:意大利 TREP 项目经验。
Pediatr Blood Cancer. 2010 May;54(5):675-80. doi: 10.1002/pbc.22385.
2
Diagnosis, treatment and outcome of pancreatoblastoma.胰腺母细胞瘤的诊断、治疗及预后
Pancreatology. 2004;4(5):441-51; discussion 452-3. doi: 10.1159/000079823. Epub 2004 Jul 14.
3
Pancreatoblastoma is associated with chromosome 11p loss of heterozygosity and IGF2 overexpression.
Med Pediatr Oncol. 2002 Jul;39(1):52-4. doi: 10.1002/mpo.10050.
4
Pancreatoblastoma in childhood: clinical course and therapeutic management of seven patients.儿童胰腺母细胞瘤:7例患者的临床病程及治疗管理
Med Pediatr Oncol. 2001 Jul;37(1):47-52. doi: 10.1002/mpo.1162.
5
Pancreatoblastoma treated by delayed operation after effective chemotherapy.有效化疗后延迟手术治疗的胰母细胞瘤
J Pediatr Surg. 2000 Nov;35(11):1663-5. doi: 10.1053/jpsu.2000.18347.