Ogawa B, Okinaga K, Obana K, Nakamura K, Hattori T, Ito T, Yanagawa Y, Tanaka F, Imamura T
Second Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
J Pediatr Surg. 2000 Nov;35(11):1663-5. doi: 10.1053/jpsu.2000.18347.
A case of pancreatoblastoma in a 4-year-old girl is presented. She was admitted with an abdominal mass and vomiting in August 1994. Computed tomography scan showed a 10- x 8- x 7-cm mass occupying both the head and body of the pancreas. Serum alpha-fetoprotein (AFP) level was 9,600 ng/mL (normal, <8.3 ng/mL). Results of open biopsy of the tumor showed pancreatoblastoma. Chemotherapy was administered using the new A-1 regimen consisting of cyclophosphamide, etoposide, pirarubicin, and cisplatin. After 3 cycles of chemotherapy, the size of the tumor was reduced to 5 x 4 x 3 cm, the portal vein became patent, and the AFP value decreased to 98.1 ng/mL. Total removal of the tumor was performed leaving the head and tail of the pancreas. Postoperative chemotherapy continued for 2 years. The patient has been disease free for 5 years, and her serum AFP remained within normal levels.
本文报告了一例4岁女童胰腺母细胞瘤的病例。她于1994年8月因腹部肿块和呕吐入院。计算机断层扫描显示一个10×8×7厘米的肿块占据了胰腺的头部和体部。血清甲胎蛋白（AFP）水平为9600纳克/毫升（正常，<8.3纳克/毫升）。肿瘤的开放活检结果显示为胰腺母细胞瘤。使用由环磷酰胺、依托泊苷、吡柔比星和顺铂组成的新A-1方案进行化疗。化疗3个周期后，肿瘤大小缩小至5×4×3厘米，门静脉通畅，AFP值降至98.1纳克/毫升。在保留胰腺头部和尾部的情况下对肿瘤进行了完整切除。术后化疗持续了2年。该患者已无病生存5年，其血清AFP水平保持在正常范围内。
