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脂肪酸结合蛋白5的高表达促进结肠癌细胞的生长和转移潜能。

High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells.

作者信息

Kawaguchi Koichiro, Senga Shogo, Kubota Chiaki, Kawamura Yuki, Ke Youqiang, Fujii Hiroshi

机构信息

Interdisciplinary Graduate School of Science and Technology Shinshu University Minami-minowa Kami-ina Nagano Japan.

Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan.

出版信息

FEBS Open Bio. 2016 Feb 11;6(3):190-9. doi: 10.1002/2211-5463.12031. eCollection 2016 Mar.

DOI:10.1002/2211-5463.12031
PMID:27047747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4794781/
Abstract

Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with disease stage and that FABP5 significantly promotes colorectal cancer cell growth and metastatic potential. Thus, FABP5 might be a promising prognostic or therapeutic biomarker candidate in human colorectal cancer.

摘要

脂肪酸结合蛋白（FABPs）负责结合和储存疏水性配体，如长链脂肪酸，并将这些配体转运至细胞内的适当区室。本研究表明，与正常结肠细胞相比，FABP5基因在结肠癌细胞中上调，其上调方式与疾病分期相关，且FABP5显著促进结肠癌细胞生长和转移潜能。因此，FABP5可能是人类结肠癌中有前景的预后或治疗生物标志物候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/2b373c1093ea/FEB4-6-190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/9361cae75a40/FEB4-6-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/7c94801e01db/FEB4-6-190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/df8cef78ca23/FEB4-6-190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/2b373c1093ea/FEB4-6-190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/9361cae75a40/FEB4-6-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/7c94801e01db/FEB4-6-190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/df8cef78ca23/FEB4-6-190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/4794781/2b373c1093ea/FEB4-6-190-g004.jpg

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