极软X射线放射生物学。II. 培养的C3H小鼠细胞（10T1/2）。
Radiobiology of ultrasoft X rays. II. Cultured C3H mouse cells (10T1/2).
作者信息
Schillaci M E, Carpenter S, Raju M R, Sebring R J, Wilder M E, Goodhead D T
机构信息
Medium Energy Physics, MP-4, MS H846, Los Alamos National Laboratory, New Mexico 87545.
出版信息
Radiat Res. 1989 Apr;118(1):83-92.
In the first paper of this series (Radiat. Res. 110, 396-412 (1987], using V79 cells, we reported that the relative biological effectiveness (RBE) of ultrasoft X rays was found to increase with decreasing energy, and the oxygen enhancement ratio (OER) was found to decrease with decreasing energy. In this report, we present RBE and OER results for 10T1/2 cells that are known to grow uniformly flat and are considerably thinner than V79 cells. Thus the variation in dose across the cell nucleus is considerably reduced. The OER results agree well with our earlier V79 results. However, the RBE values for 10T1/2 cells compared to V79 cells are systematically less for all soft X rays and especially for 0.28 keV carbon-K (1.3 compared to 3.4 for V79 cells). Some plausible explanations are presented to reconcile the apparent discrepancy between V79 and 10T1/2 results.
在本系列的第一篇论文（《辐射研究》110, 396 - 412 (1987)）中，我们使用V79细胞报告称，发现超软X射线的相对生物效能（RBE）随能量降低而增加，并且氧增强比（OER）随能量降低而降低。在本报告中，我们给出了10T1/2细胞的RBE和OER结果，已知该细胞生长均匀扁平且比V79细胞薄得多。因此，穿过细胞核的剂量变化显著减小。OER结果与我们早期对V79细胞的结果非常吻合。然而，对于所有软X射线，尤其是对于0.28 keV的碳 - K射线，10T1/2细胞的RBE值与V79细胞相比系统性地更低（V79细胞为3.4，10T1/2细胞为1.3）。我们提出了一些合理的解释来调和V79细胞和10T1/2细胞结果之间明显的差异。
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