Yang C Y, Li B Y, Xu P, Yang Y J, Yang Q Z
Clin Exp Obstet Gynecol. 2016;43(1):149-53.
To evaluate the clinical significance of serum albumin (ALB) levels in the early evaluation and prognosis of preterm infants in the neonatal intensive care units (NICUs).
The authors collected and retrospectively analyzed complete clinical records of preterm infants admitted to the NICU from July 2012 to March 2013. The cases were divided into three groups according to their ALB levels: ≥ 30 g/L, 25-30 g/L, and ≤ 25 g/L.
The mean gestational age in the ≤ 25 g/L ALB group was significantly higher than that in the ≥ 30 g/L ALB group [(33.41 ± 2.15) weeks] (p < 0.05). The prealbumin, blood platelet, and blood urea nitrogen in the ≤ 25 g/L ALB group were significantly lower than those in the ≥ 30 g/L ALB group (p < 0.05). In addition, serum lactate in the ≤ 25 g/L ALB group was significantly higher than that in the ≥ 30 g/L ALB group (p < 0.05).
Serum ALB level increased with increasing gestational age. Lower ALB levels were associated with more perinatal complications, damage to multiple organs, more severe cases, and mechanical ventilation, which resulted in longer hospital stays and poorer prognoses.
评估新生儿重症监护病房（NICU）中血清白蛋白（ALB）水平在早产儿早期评估及预后中的临床意义。
作者收集并回顾性分析了2012年7月至2013年3月入住NICU的早产儿的完整临床记录。根据ALB水平将病例分为三组：≥30 g/L、25 - 30 g/L和≤25 g/L。
≤25 g/L ALB组的平均胎龄显著高于≥30 g/L ALB组[（33.41 ± 2.15）周]（p < 0.05）。≤25 g/L ALB组的前白蛋白、血小板和血尿素氮显著低于≥30 g/L ALB组（p < 0.05）。此外，≤25 g/L ALB组的血清乳酸显著高于≥30 g/L ALB组（p < 0.05）。
血清ALB水平随胎龄增加而升高。较低的ALB水平与更多围产期并发症、多器官损伤、更严重病例及机械通气相关，导致住院时间延长和预后较差。
