慢性肾脏病中的骨质流失：量还是质？
Bone loss in chronic kidney disease: Quantity or quality?
作者信息
Zheng Cai-Mei, Zheng Jin-Quan, Wu Chia-Chao, Lu Chien-Lin, Shyu Jia-Fwu, Yung-Ho Hsu, Wu Mei-Yi, Chiu I-Jen, Wang Yuan-Hung, Lin Yuh-Feng, Lu Kuo-Cheng
机构信息
Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan; Division of Pulmonary and Critical Care, Department of Critical Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan.
出版信息
Bone. 2016 Jun;87:57-70. doi: 10.1016/j.bone.2016.03.017. Epub 2016 Apr 2.
Chronic kidney disease (CKD) patients experience bone loss and fracture because of a specific CKD-related systemic disorder known as CKD-mineral bone disorder (CKD-MBD). The bone turnover, mineralization, and volume (TMV) system describes the morphological bone lesions in renal osteodystrophy related to CKD-MBD. Bone turnover and bone volume are defined as high, normal, or low, and bone mineralization is classified as normal or abnormal. All types of bone histology related to TMV are responsible for both bone quantity and bone quality losses in CKD patients. This review focuses on current bone quantity and bone quality losses in CKD patients and finally discusses potential therapeutic measures.
慢性肾脏病（CKD）患者会因一种特定的与CKD相关的全身性疾病——CKD-矿物质与骨代谢紊乱（CKD-MBD）而出现骨质流失和骨折。骨转换、矿化和体积（TMV）系统描述了与CKD-MBD相关的肾性骨营养不良中的形态学骨病变。骨转换和骨体积被定义为高、正常或低，骨矿化被分类为正常或异常。与TMV相关的所有类型的骨组织学都导致了CKD患者的骨量和骨质量损失。本综述重点关注CKD患者当前的骨量和骨质量损失，最后讨论潜在的治疗措施。
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