Tsukamoto Yusuke
Shuwa General Hospital, Division of Nephrology, Japan.
Clin Calcium. 2007 May;17(5):660-4.
Since vascular calcification due to mineral disorder has been revealed a chief cause of decreasing life expectancy of chronic kidney disease (CKD) patients in recent years, the term "renal osteodystrophy" can no longer express the pathophysiology of entire bone and mineral disorder in CKD. This is the reason why new disease entity "CKD-bone mineral disorden (MBD)" was introduced by the GBMI (Global Bone and Mineral Initiative) (one of the workgroups of KDIGO [Kidney Disease Improving Global Outcome]). GBMI has also produced new pathological classification of renal osteodystrophy (ROD) as TMV (turnover, mineralization, volume) classification and LBC (laboratory abnormalities, bone abnormalities, extra osseous calcification) classification for CKD-MBD.
近年来,由于矿物质紊乱导致的血管钙化已被揭示为慢性肾脏病(CKD)患者预期寿命降低的主要原因,因此术语“肾性骨营养不良”已无法表达CKD中整个骨与矿物质紊乱的病理生理学。这就是全球骨与矿物质倡议组织(GBMI,KDIGO[改善全球肾脏病预后组织]的一个工作组)引入新的疾病实体“CKD-骨矿物质紊乱(MBD)”的原因。GBMI还针对CKD-MBD制定了肾性骨营养不良(ROD)的新病理分类,即TMV(转换、矿化、体积)分类和LBC(实验室异常、骨异常、骨外钙化)分类。