三氯硅烷还原酰肼反应：一种制备 1,1-二取代腙的方法。
Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines.
机构信息
Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 China.
Graduate School of Chinese Academy of Sciences , Beijing, 10049, China.
出版信息
Org Lett. 2016 Apr 15;18(8):1900-3. doi: 10.1021/acs.orglett.6b00675. Epub 2016 Apr 6.
PMID:27049166
Abstract
A straightforward and facile method has been developed to prepare 1,1-disubstituted hydrazines via Lewis base promoted direct reductive hydrazination. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes could react with phenylhdrazines to prepare 1,1-disubstituted hydrazines with good to high yields.
摘要
本文发展了一种通过路易斯碱促进的直接还原酰化肼化反应来制备 1,1-二取代腙的简便方法。在六甲基磷酰胺（HMPA）和 N,N-二甲基乙酰胺（DMAc）分别催化下，各种酮和醛与苯肼反应，以良好至高的产率得到 1,1-二取代腙。
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