Chen Y Y, Wang B N, Yu X P
Cardiovascular Medicine Unit, Shenzhen Second People's Hospital Affiliated to Anhui Medical University, The Second People's Hospital of Shenzhen City, Shenzhen, China.
Cardiovascular Medicine Unit, The First Affiliated Hospital of Anhui Medical University City, Hefei, China.
Genet Mol Res. 2016 Mar 28;15(1):gmr7238. doi: 10.4238/gmr.15017238.
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An additional 200 healthy volunteers were enrolled as the control group. Serum HCY levels, MTHFR C677T genotype, and other related indicators were evaluated for the two groups. Compared to those in the control group, the serum HCY levels in the CHD patients were significantly higher (P < 0.05). The proportion of individuals with the heterozygous MTHFR CT genotype and homozygous mutant TT genotype among CHD patients was significantly higher than that in the control group (P < 0.05). In the acute coronary syndrome (ACS) subgroup, the proportion of those with the CT and TT genotypes was significantly higher than that of the stable CHD subgroup (P < 0.05). In summary, serum HCY levels were elevated in CHD patients, and the frequency of the CT and TT genotypes were also significantly increased, especially among the ACS subgroup. Taken together, this suggests that serum HCY levels and MTHFR C677T genotypes are correlated with CHD.
本研究的目的是探讨血清同型半胱氨酸（HCY）水平与亚甲基四氢叶酸还原酶（MTHFR）基因677C/T多态性及冠心病（CHD）之间的相关性。我们连续纳入了本院208例经CTA或冠状动脉造影确诊的冠心病患者。另外招募200名健康志愿者作为对照组。对两组患者的血清HCY水平、MTHFR C677T基因型及其他相关指标进行评估。与对照组相比，冠心病患者的血清HCY水平显著更高（P < 0.05）。冠心病患者中MTHFR CT杂合基因型和TT纯合突变基因型个体的比例显著高于对照组（P < 0.05）。在急性冠状动脉综合征（ACS）亚组中，CT和TT基因型患者的比例显著高于稳定型冠心病亚组（P < 0.05）。总之，冠心病患者血清HCY水平升高，CT和TT基因型的频率也显著增加，尤其是在ACS亚组中。综上所述，这表明血清HCY水平和MTHFR C677T基因型与冠心病相关。
