喹唑啉酮和喹唑啉衍生物：具有强效抗菌和细胞毒性活性的新型结构
Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities.
作者信息
Jafari Elham, Khajouei Marzieh Rahmani, Hassanzadeh Farshid, Hakimelahi Gholam Hossein, Khodarahmi Ghadam Ali
机构信息
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
出版信息
Res Pharm Sci. 2016 Jan-Feb;11(1):1-14.
Abstract
The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.
摘要
杂环化合物在药物化学中具有重要意义。药物化学中最重要的杂环之一是喹唑啉，它具有广泛的生物学特性，如抗菌、抗真菌、抗惊厥、抗炎、抗HIV、抗癌和镇痛活性。这种骨架是一种重要的药效基团，被视为一种优势结构。本文综述了具有强效抗菌和细胞毒性活性的喹唑啉和喹唑啉酮衍生物合成方面的最新进展。
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