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喹唑啉和喹唑酮衍生物作为抗结核药物的前景展望。

An Insight on the Prospect of Quinazoline and Quinazolinone Derivatives as Anti-tubercular Agents.

机构信息

Sri Aurobindo Institute of Pharmacy, Indore, MP, India.

Department of Pharmaceutical Sciences, Harisingh Gour Vishwavidyalaya, Sagar, MP, India.

出版信息

Curr Org Synth. 2023;20(8):838-869. doi: 10.2174/1570179420666230316094435.

Abstract

Multiple potential drugs have been developed based on the heterocyclic molecules for the treatment of different symptoms. Among the existing heterocyclic molecules, quinazoline and quinazolinone derivatives have been found to exhibit extensive pharmacological and biological characteristics. One significant property of these molecules is their potency as anti-tubercular agents. Thus, both quinazoline and quinazolinone derivatives are modified using different functional groups as substituents for investigating their anti-tubercular activities. We present a summary of the reported anti-tubercular drugs, designed using quinazoline and quinazolinone derivatives, in this review.

摘要

已经基于杂环分子开发了多种潜在药物,用于治疗不同的症状。在现有的杂环分子中,已发现喹唑啉和喹唑啉酮衍生物具有广泛的药理和生物学特性。这些分子的一个重要特性是它们作为抗结核药物的效力。因此,喹唑啉和喹唑啉酮衍生物都使用不同的官能团进行修饰,作为取代基来研究它们的抗结核活性。在这篇综述中,我们总结了报道的使用喹唑啉和喹唑啉酮衍生物设计的抗结核药物。

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