[寻找新型合成利尿剂]
[SEARCHING FOR NEW SYNTHETIC DIURETICS].
作者信息
Smirnov I V, Murashko T O, Ivanov A A, Nemtsev A O, Bondarev A A, Udut V V
出版信息
Eksp Klin Farmakol. 2015;78(12):3-5.
This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 µmol/kg from 1st to 7th day and 54 µmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophenyl-O-β-D-glucopyranoside in a dose of 54 µmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.
本研究旨在评估4-硝基苯基-O-β-D-吡喃葡萄糖苷及其苷元4-硝基苯酚对大鼠的利尿和促尿钠排泄活性。从第1天至第7天，实验动物每日以18 µmol/kg的剂量、第8天至第14天以54 µmol/kg的剂量，通过胃内给予2 mL蒸馏水的方式分别给予4-硝基苯基-O-β-D-吡喃葡萄糖苷（第1组）和4-硝基苯酚（第2组）。实验期间，观察到剂量为54 µmol/kg的4-硝基苯基-O-β-D-吡喃葡萄糖苷具有最显著的利尿活性，与对照组相比，其使大鼠尿量增加了2.5倍。
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