Samuelsson Ulf, Anderzén Johan, Gudbjörnsdottir Soffia, Steineck Isabelle, Åkesson Karin, Hanberger Lena
Dept. of Clinical and Experimental Medicine, Division of Paediatrics, Linköping University, Linköping, Sweden.
Dept. of Paediatrics, Ryhov County Hospital, Jönköping, Sweden.
J Diabetes Complications. 2016 Jul;30(5):917-22. doi: 10.1016/j.jdiacomp.2016.02.007. Epub 2016 Feb 9.
To compare metabolic control between males and females with type 1 diabetes during adolescence and as young adults, and relate it to microvascular complications.
Data concerning 4000 adolescents with type 1 diabetes registered in the Swedish paediatric diabetes quality registry, and above the age of 18years in the Swedish National Diabetes Registry was used.
When dividing HbA1c values in three groups; < 7.4% (57mmol/mol), 7.4-9.3% (57-78mmol/mol) and >9.3% (78mmol/mol), there was a higher proportion of females in the highest group during adolescence. In the group with the highest HbA1c values during adolescence and as adults, 51.7% were females, expected value 46.2%; in the group with low HbA1c values in both registries, 34.2% were females, p<0.001. As adults, more females had retinopathy, p<0.05. Females had higher mean HbA1c values at diagnosis, 11.2 vs. 10.9% (99 vs. 96mmol/mol), p<0.03, during adolescence, 8.5 vs. 8.2% (69 vs. 66mmol/mol) p<0.01, but not as young adults.
Worse glycaemic control was found in adolescent females, and they had a higher frequency of microvascular complications. Improved paediatric diabetes care is of great importance for increasing the likelihood of lower mortality and morbidity later in life.
比较青少年及青年1型糖尿病男性与女性之间的代谢控制情况，并将其与微血管并发症相关联。
使用瑞典儿科糖尿病质量登记处登记的4000名1型糖尿病青少年以及瑞典国家糖尿病登记处中18岁以上患者的数据。
将糖化血红蛋白（HbA1c）值分为三组：<7.4%（57mmol/mol）、7.4 - 9.3%（57 - 78mmol/mol）和>9.3%（78mmol/mol），青春期最高组中女性比例更高。在青春期及成年期HbA1c值最高的组中，女性占51.7%，预期值为46.2%；在两个登记处HbA1c值均较低的组中，女性占34.2%，p<0.001。成年后，更多女性患有视网膜病变，p<0.05。青春期时，女性诊断时的平均HbA1c值更高，分别为11.2%对10.9%（99对96mmol/mol），p<0.03，青春期时为8.5%对8.2%（69对66mmol/mol），p<0.01，但成年后并非如此。
青春期女性血糖控制较差，且微血管并发症发生率更高。改善儿科糖尿病护理对于降低日后生活中死亡率和发病率的可能性非常重要。
