Orban Guy A
Department of Neuroscience, University of Parma, Parma, Italy
Proc Biol Sci. 2016 Apr 13;283(1828). doi: 10.1098/rspb.2016.0118.
Establishing homologies between cortical areas in animal models and humans lies at the heart of translational neuroscience, as it demonstrates how knowledge obtained from these models can be applied to the human brain. Here, we review progress in using parallel functional imaging to ascertain homologies between parietal areas of human and non-human primates, species sharing similar behavioural repertoires. The human homologues of several areas along monkey IPS involved in action planning and observation, such as AIP, LIP and CIP, as well as those of opercular areas (SII complex), have been defined. In addition, uniquely human areas, such as the tool-use area in left anterior supramarginal gyrus, have also been identified.
在动物模型和人类的皮质区域之间建立同源性是转化神经科学的核心,因为它展示了从这些模型中获得的知识如何应用于人类大脑。在这里,我们回顾了使用平行功能成像来确定人类和非人类灵长类动物顶叶区域之间同源性的进展,这两个物种具有相似的行为模式。已经确定了猴子顶内沟(IPS)沿线几个参与动作规划和观察的区域的人类同源物,如前顶内沟(AIP)、侧顶内沟(LIP)和中央顶内沟(CIP),以及岛盖区域(第二躯体感觉区复合体)的同源物。此外,还发现了独特的人类区域,如左前顶上小叶的工具使用区域。