Furmanek Mariusz P, Schettino Luis F, Yarossi Mathew, Mangalam Madhur, Lockwood Kyle, Adamovich Sergei V, Tunik Eugene
Department of Physical Therapy, University of Rhode Island, Kingston, Rhode Island 02881
Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts 02115.
J Neurosci. 2025 Mar 19;45(12):e0173242025. doi: 10.1523/JNEUROSCI.0173-24.2025.
Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector's state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP) networks are involved in the control of prehension, with dorsomedial (DM) and dorsolateral (DL) regions processing the reach and the grasp, respectively. This study tested (five female and five male participants) the differential involvement of FP nodes [ventral premotor cortex (PMv), dorsal premotor cortex (PMd), anterior intraparietal sulcus (aIPS), and anterior superior parieto-occipital cortex (aSPOC)] in online adjustments of reach-to-grasp coordination to mechanical perturbations (MP) that disrupted arm transport. We used event-related transcranial magnetic stimulation (TMS) to test whether the nodes of these pathways causally contribute to the processing of proprioceptive information when reaching for a virtual visual target at two different perturbation latencies. TMS over aSPOC selectively altered the correction magnitude of arm transport during late perturbations, demonstrating that aSPOC processes proprioceptive inputs related to mechanical perturbations in a movement phase-dependent manner.
人类通过效应器状态、运动指令和感觉反馈的多感官整合，轻松地根据不断变化的环境调整自身运动。据推测，额顶叶（FP）网络参与抓握控制，其中背内侧（DM）和背外侧（DL）区域分别处理伸展和抓握动作。本研究测试了（五名女性和五名男性参与者）FP节点[腹侧运动前皮层（PMv）、背侧运动前皮层（PMd）、顶内沟前部（aIPS）和顶枕叶前部皮层（aSPOC）]在对破坏手臂运输的机械扰动（MP）进行抓握协调在线调整时的不同参与情况。我们使用事件相关经颅磁刺激（TMS）来测试在两个不同的扰动潜伏期伸手去够虚拟视觉目标时，这些通路的节点是否因果性地参与本体感觉信息的处理。在aSPOC上施加TMS在后期扰动期间选择性地改变了手臂运输的校正幅度，表明aSPOC以运动阶段依赖的方式处理与机械扰动相关的本体感觉输入。
