突触前功能和疾病中的膜脂

Membrane Lipids in Presynaptic Function and Disease.

机构信息

Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, Leuven Institute for Neurodegenerative Disease, Herestraat 49, Bus 602, 3000 Leuven, Belgium.

出版信息

Neuron. 2016 Apr 6;90(1):11-25. doi: 10.1016/j.neuron.2016.02.033.

DOI:10.1016/j.neuron.2016.02.033

PMID:27054615

Abstract

Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.

摘要

脂质是大脑中最丰富的有机化合物。大脑具有独特的脂质组，脂质浓度、组织和代谢的变化与许多神经元疾病有关。在这里，我们讨论了对突触前膜脂质组织理解的最新进展，重点介绍了脂质本身如何调节膜运输和控制蛋白质活性的说明性例子。这一见解强调了突触前末梢是膜重塑机器，脂质和蛋白质分子之间的合作是突触前活动的基础。