黄疸型Gunn大鼠的脑干听觉诱发电位

Brain stem auditory evoked potentials in jaundiced Gunn rats.

作者信息

Shapiro S M, Hecox K E

机构信息

Department of Neurology, Waisman Center on Mental Retardation and Human Development, University of Wisconsin, Madison.

出版信息

Ann Otol Rhinol Laryngol. 1989 Apr;98(4 Pt 1):308-17. doi: 10.1177/000348948909800414.

DOI:10.1177/000348948909800414

PMID:2705705

Abstract

Bilirubin encephalopathy causes potentially preventable brain damage and hearing loss. The site of auditory dysfunction is controversial, despite pathologic studies showing damage to brain stem auditory nuclei in humans and experimental animals. We studied the effects of bilirubin toxicity on the auditory system of homozygous jaundiced Gunn rats by use of brain stem auditory evoked potentials. Small but statistically significant abnormalities were found for wave latencies, interwave intervals, and amplitudes.

摘要

胆红素脑病可导致潜在的可预防的脑损伤和听力丧失。尽管病理学研究表明人类和实验动物的脑干听觉核受损，但听觉功能障碍的部位仍存在争议。我们通过脑干听觉诱发电位研究了胆红素毒性对纯合黄疸Gunn大鼠听觉系统的影响。发现波潜伏期、波间期和波幅存在微小但具有统计学意义的异常。