Levi G, Sohmer H, Kapitulnik J
Arch Otorhinolaryngol. 1981;232(2):139-43. doi: 10.1007/BF00505033.
In humans, functional evidence based on recording cochlear microphonic, auditory nerve, and brain stem responses has shown that the site of lesion in hearing loss following neonatal hyperbilirubinemia is the auditory nerve (with sparing of the hair cells). Structural damage to the central nervous system (CNS) including the cochlear nuclei has been demonstrated in adult, homozygous Gunn rats which develop hyperbilirubinemia shortly after birth. In an attempt to use the Gunn rat as an experimental model for bilirubin-induced CNS damage, auditory nerve and brain stem responses (ABR) were recorded in jaundiced (homozygous) and non-jaundiced (heterozygous) Gunn rats and in Sabra (Wistar) rats. All of the rats including the jaundiced Gunn rats had normal ABR and responded behaviorally to sound stimuli. These results suggest that the adult jaundiced Gunn rat retains auditory function and in this way differs from human patients in whom neonatal jaundice has lead to hearing loss. Therefore, the adult homozygous Gunn rat probably cannot serve as a model for hearing loss due to hyperbilirubinemia.
在人类中，基于记录耳蜗微音电位、听神经和脑干反应的功能证据表明，新生儿高胆红素血症后听力损失的病变部位是听神经（毛细胞未受影响）。在出生后不久发生高胆红素血症的成年纯合子Gunn大鼠中，已证实包括耳蜗核在内的中枢神经系统（CNS）存在结构损伤。为了将Gunn大鼠用作胆红素诱导的中枢神经系统损伤的实验模型，对黄疸（纯合子）和非黄疸（杂合子）Gunn大鼠以及Sabra（Wistar）大鼠记录了听神经和脑干反应（ABR）。所有大鼠，包括黄疸Gunn大鼠，ABR均正常，并且对声音刺激有行为反应。这些结果表明，成年黄疸Gunn大鼠保留了听觉功能，在这方面与新生儿黄疸导致听力损失的人类患者不同。因此，成年纯合子Gunn大鼠可能不能用作高胆红素血症所致听力损失的模型。
