免疫原性细胞死亡相关生物标志物：对辅助化疗后乳腺癌患者生存的影响。
Immunogenic cell death-related biomarkers: Impact on the survival of breast cancer patients after adjuvant chemotherapy.
作者信息
Ladoire Sylvain, Enot David, Andre Fabrice, Zitvogel Laurence, Kroemer Guido
机构信息
Department of Medical Oncology, Georges François Leclerc Center,Dijon, France; Institut National de la Santé et de la Recherche Médicale, Avenir Team INSERM, CRI-866 University of Burgundy, Dijon, France; Institut National de la Santé et de la Recherche Médicale, U1015, Equipe labellisée Ligue Nationale Contre le Cancer, INSERM U1015, Institut Gustave Roussy, Villejuif, France.
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus , Villejuif, France.
出版信息
Oncoimmunology. 2015 Aug 31;5(2):e1082706. doi: 10.1080/2162402X.2015.1082706. eCollection 2016 Feb.
Abstract
It is well established that the anticancer immune response determines the success of anthracycline-based adjuvant chemotherapy of breast cancer. This effect is in part due to the capacity of anthracyclines to induce immunogenic cell death (ICD), a cell death modality that is preceded by autophagy and followed by HMGB1 release. Recent data on 1,798 mammary carcinoma specimens indicate that patients harboring neoplastic cells that lack immunohistochemical signs of autophagy or that have lost HMGB1 expression have indeed a poor prognosis.
摘要
众所周知，抗癌免疫反应决定了基于蒽环类药物的乳腺癌辅助化疗的成败。这种效应部分归因于蒽环类药物诱导免疫原性细胞死亡（ICD）的能力，免疫原性细胞死亡是一种细胞死亡方式，其先于自噬发生，随后伴有HMGB1释放。最近对1798份乳腺癌标本的研究数据表明，肿瘤细胞缺乏自噬免疫组化迹象或HMGB1表达缺失的患者，其预后确实较差。
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