Kurumaya H, Yoshida K, Kono N, Nakanuma Y, Takeda S, Oiko Y
Second Department of Pathology, School of Medicine Kanazawa University, Japan.
Arch Pathol Lab Med. 1989 Apr;113(4):411-3.
Hepatic calcification in uremia is rare and, to our knowledge, only two cases have been reported in the English literature. In both previous reports, calcification was found in the damaged hepatocytes in the centrilobular to midzonal area of the hepatic lobules. The patient, a 61-year-old man, was uremic due to diabetic nephropathy. He had suffered posttransfusion hepatitis just before his death. Antemortem radiographic examination of the abdomen failed to visualize the calcification in the liver. At autopsy, microscopic examination of the liver revealed bile ductular proliferation and calcification mainly in the ductular epithelial cells. We suggest that calcification could occur preferentially in abnormally proliferated ductules when the serum calcium and serum phosphorus products are elevated.
尿毒症患者肝脏钙化罕见，据我们所知，英文文献中仅报道过两例。在之前的两份报告中，钙化均见于肝小叶中央静脉至中间带区域受损的肝细胞内。该患者为一名61岁男性，因糖尿病肾病导致尿毒症。他在死前曾患输血后肝炎。生前腹部影像学检查未能发现肝脏钙化。尸检时，肝脏显微镜检查显示胆管增生，钙化主要见于胆管上皮细胞。我们认为，当血清钙和血清磷乘积升高时，钙化可能优先发生于异常增生的小胆管。
