Sugiura H, Yoshida K, Nakanuma Y, Ohta G, Izumino K, Takazakura H
Am J Gastroenterol. 1987 Aug;82(8):786-9.
Hepatocellular calcification is extremely rare and only one case has been recorded in the literature. The patient, a 74-yr-old Japanese woman, received hemodialysis for 5 months because of uremia due to chronic glomerulonephritis. Four months before death, she was once in a state of shock which lasted for 4 h due to massive hemorrhage from the shunt vein for hemodialysis. She died of disseminated intravascular coagulopathy and respiratory failure due to uremia. Postmortem liver biopsy showed centri- and midzonal necrosis associated with septal fibrosis where intracellular and extracellular calcification were noted. The calcifications were round or rod shaped and single or multiple in distribution. The calcification was thought to occur as the result of shock, which caused hepatocellular damage, due to consumption of a high calcium-phosphorus product.
肝细胞钙化极为罕见，文献中仅记载过一例。该患者为一名74岁的日本女性，因慢性肾小球肾炎导致尿毒症接受了5个月的血液透析。在死亡前4个月，她曾因血液透析分流静脉大量出血而处于休克状态，持续了4小时。她死于弥散性血管内凝血和尿毒症导致的呼吸衰竭。尸检肝脏活检显示中央和中间带坏死并伴有间隔纤维化，可见细胞内和细胞外钙化。钙化呈圆形或棒状，分布为单个或多个。钙化被认为是休克导致肝细胞损伤的结果，休克是由于高钙磷产物的消耗引起的。
