Henderson V W, Mack W, Williams B W
Department of Neurology, University of Southern California, Los Angeles.
Arch Neurol. 1989 Apr;46(4):391-4. doi: 10.1001/archneur.1989.00520400045018.
Spatial disorientation was investigated in 28 ambulatory patients meeting the National Institute of Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association Work Group criteria for "probable" Alzheimer's disease. Based on caregivers' reports, 39% of subjects engaged in at least three of four behavioral measures of spatial disorientation three or more times a week; these patients did not significantly differ from other Alzheimer's disease subjects with regard to age, sex, education, or symptom duration. Using stepwise regression analysis, we found that neuropsychologic measures of memory and visuoconstructive functions, but not disease severity, attention, or language impairment, emerged as significant predictors of spatial disorientation. In the setting of impaired memory, the tendency of some patients with Alzheimer's disease to wander or to get lost may implicate particularly severe dysfunction of right hemisphere neocortical areas concerned with visuospatial processes.
对28名符合美国国立神经疾病和中风研究所 - 阿尔茨海默病及相关疾病协会工作组“可能的”阿尔茨海默病标准的门诊患者进行了空间定向障碍的研究。根据护理人员的报告，39%的受试者每周三次或更多次出现四项空间定向行为指标中的至少三项；这些患者在年龄、性别、教育程度或症状持续时间方面与其他阿尔茨海默病患者没有显著差异。通过逐步回归分析，我们发现记忆和视觉构建功能的神经心理学指标，而非疾病严重程度、注意力或语言障碍，是空间定向障碍的显著预测因素。在记忆受损的情况下，一些阿尔茨海默病患者徘徊或迷路的倾向可能意味着与视觉空间过程相关的右半球新皮质区域功能特别严重受损。
