Xia Ning, Daiber Andreas, Förstermann Ulrich, Li Huige
Department of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
2nd Medical Department, Cardiology and Angiology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Br J Pharmacol. 2017 Jun;174(12):1633-1646. doi: 10.1111/bph.13492. Epub 2016 May 6.
The antioxidant effects of resveratrol (3,5,4'-trihydroxy-trans-stilbene) contribute substantially to the health benefits of this compound. Resveratrol has been shown to be a scavenger of a number of free radicals. However, the direct scavenging activities of resveratrol are relatively poor. The antioxidant properties of resveratrol in vivo are more likely to be attributable to its effect as a gene regulator. Resveratrol inhibits NADPH oxidase-mediated production of ROS by down-regulating the expression and activity of the oxidase. This polyphenolic compound reduces mitochondrial superoxide generation by stimulating mitochondria biogenesis. Resveratrol prevents superoxide production from uncoupled endothelial nitric oxide synthase by up-regulating the tetrahydrobiopterin-synthesizing enzyme GTP cyclohydrolase I. In addition, resveratrol increases the expression of various antioxidant enzymes. Some of the gene-regulating effects of resveratrol are mediated by the histone/protein deacetylase sirtuin 1 or by the nuclear factor-E2-related factor-2. In this review article, we have also summarized the cardiovascular effects of resveratrol observed in clinical trials.
This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc.
白藜芦醇（3,5,4'-三羟基反式芪）的抗氧化作用对该化合物的健康益处有很大贡献。白藜芦醇已被证明是多种自由基的清除剂。然而，白藜芦醇的直接清除活性相对较差。白藜芦醇在体内的抗氧化特性更可能归因于其作为基因调节剂的作用。白藜芦醇通过下调氧化酶的表达和活性来抑制NADPH氧化酶介导的活性氧生成。这种多酚化合物通过刺激线粒体生物发生来减少线粒体超氧化物的产生。白藜芦醇通过上调四氢生物蝶呤合成酶GTP环化水解酶I来防止非偶联内皮型一氧化氮合酶产生超氧化物。此外，白藜芦醇可增加多种抗氧化酶的表达。白藜芦醇的一些基因调节作用是由组蛋白/蛋白质去乙酰化酶sirtuin 1或核因子E2相关因子2介导的。在这篇综述文章中，我们还总结了在临床试验中观察到的白藜芦醇对心血管的影响。
本文是关于健康与疾病中的氧化还原生物学和氧化应激主题部分的一部分。要查看本部分的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc。
