阻塞性睡眠呼吸暂停与早产风险
Obstructive sleep apnea and the risk of preterm delivery.
作者信息
Na-Rungsri Kunyalak, Lertmaharit Somrat, Lohsoonthorn Vitool, Totienchai Surachart, Jaimchariyatam Nattapong
机构信息
Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Physical Medicine and Rehabilitation, Maharat Nakhon Ratchasima Hospital, Amphur Muang, Nakhon Ratchasima Province, Thailand.
出版信息
Sleep Breath. 2016 Sep;20(3):1111-7. doi: 10.1007/s11325-016-1339-7. Epub 2016 Apr 8.
OBJECTIVE
The aim of this study was to evaluate the risk of obstructive sleep apnea (OSA) to preterm delivery (PTD), using the Berlin Questionnaire (BQ).
METHODS
This was a large, prospective cohort study among pregnant Thai women. The BQ was employed for symptom-based OSA screening during the second trimester, and PTD was recorded in 1345 pregnant women. Multivariate models were applied in controlling for potential confounders.
RESULTS
The overall prevalence of the high risk of OSA was 10.1 %, and it was significantly associated with pre-pregnancy body mass index and score on the Perceived Stress Scale. An adjusted odds ratio for PTD in women with a high risk of OSA was 2.00 (95 % confidence intervals (CIs) = 1.20, 3.34). Stratified analyses, after adjusting for confounding factors, indicated that a high risk of OSA was associated with an increased risk of spontaneous preterm delivery (odds ratio (OR) = 2.45, 95 % CI = 1.20, 5.02), but not with preterm premature rupture of membranes (OR = 1.61, 95 % CI = 0.61, 4.26), and medically indicated preterm delivery (OR = 1.83, 95 % CI = 0.72, 4.64).
CONCLUSION
Pregnant women with a high risk of OSA are at an increased risk of having PTD, compared with pregnant women with a low risk of OSA.
目的
本研究旨在使用柏林问卷（BQ）评估阻塞性睡眠呼吸暂停（OSA）与早产（PTD）的风险。
方法
这是一项针对泰国孕妇的大型前瞻性队列研究。在孕中期使用BQ进行基于症状的OSA筛查，记录了1345名孕妇的早产情况。应用多变量模型控制潜在混杂因素。
结果
OSA高风险的总体患病率为10.1%，且与孕前体重指数和感知压力量表得分显著相关。OSA高风险女性发生PTD的校正比值比为2.00（95%置信区间（CI）=1.20，3.34）。在调整混杂因素后的分层分析表明，OSA高风险与自然早产风险增加相关（比值比（OR）=2.45，95%CI=1.20，5.02），但与胎膜早破早产（OR=1.61，95%CI=0.61，4.26）和医源性早产（OR=1.83，95%CI=0.72，4.64）无关。
结论
与OSA低风险的孕妇相比，OSA高风险的孕妇发生PTD的风险增加。
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