Pickering J W, Butler P H, Ring B J, Walker E P
Australas Phys Eng Sci Med. 1989 Mar;12(1):11-5.
Thermal profiles of ectatic capillaries, modelled on those found in port wine stain birthmarks, are calculated by a method of finite differences. Yellow 578nm light is assumed to illuminate these vessels. The coagulation of endothelial cells is assumed to occur when the cells are heated to at least 70 degrees C. We model this by asking that a point 6 microns above the top of the vessel lumen attains a temperature of 70 degrees C. We constrain the parameters to prevent heating of blood above 100 degrees C, so as to avoid vapourisation. The treatment parameters of dose and illumination time are varied until they produce thermal profiles that show the model's coagulation conditions. being treated and are rather longer than the thermal relaxation time of the vessel and also much longer than the pulses of pulsed dye lasers.
基于葡萄酒色斑胎记中发现的扩张毛细血管的热分布,采用有限差分法进行计算。假设用578nm的黄光照射这些血管。当内皮细胞被加热到至少70摄氏度时,假定会发生内皮细胞的凝固。我们通过要求血管腔顶部上方6微米处的一点达到70摄氏度来对此进行建模。我们对参数进行约束,以防止血液温度超过100摄氏度,从而避免汽化。改变剂量和照射时间等治疗参数,直到它们产生显示模型凝固条件的热分布。正在接受治疗,并且比血管的热弛豫时间长得多,也比脉冲染料激光的脉冲长得多。