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氩激光凝固过程中鲜红斑痣模型的温度变化

Temperature behaviour of a model port-wine stain during argon laser coagulation.

作者信息

van Gemert M J, de Kleijn W J, Henning J P

出版信息

Phys Med Biol. 1982 Sep;27(9):1089-104. doi: 10.1088/0031-9155/27/9/001.

Abstract

Temperature calculations on a model of a port-wine stain during argon laser coagulation have been performed. The model consists of four plane parallel layers representing the epidermis, the upper dermis, the superficial capillary blood plexus, and the deeper dermis. The light distribution inside the skin is calculated on the basis of the Kubelka-Munk theory. The numerical calculations have been performed by an 'alternating-direction-implicit' finite difference method. For the usual combination of exposure time and beam radius of the argon laser (between 0.1 and 0.6 s, and 0.5 mm or 1 mm) the shortest exposure time and largest beam radius yields the most efficient plexus coagulation. The model confirms that plexus coagulation implies destruction of epidermis and stratum papillare. Heat summation effects at the laser spot boundaries can be avoided when a distance of 2.5 times the beam radius is used between adjacent spots (centre-to-centre). An optimal argon laser treatment technique is suggested yielding full plexus coagulation with minimal or no scarring. Two simple physical requirements are given for the ideal laser to coagulate port-wine stains in an efficient and selective manner, suggesting application of pulsed dye lasers, emitting either at 418 nm or at 577 nm.

摘要

已对氩激光凝固过程中鲜红斑痣模型进行了温度计算。该模型由代表表皮、真皮上层、浅表毛细血管丛和真皮深层的四个平面平行层组成。基于库贝尔卡 - 蒙克理论计算皮肤内部的光分布。数值计算采用“交替方向隐式”有限差分法进行。对于氩激光通常的曝光时间和光束半径组合(0.1至0.6秒之间,光束半径为0.5毫米或1毫米),最短曝光时间和最大光束半径可实现最有效的毛细血管丛凝固。该模型证实毛细血管丛凝固意味着表皮和乳头层的破坏。当相邻光斑(中心到中心)之间的距离为光束半径的2.5倍时,可避免激光光斑边界处的热累积效应。提出了一种最佳氩激光治疗技术,可实现完全的毛细血管丛凝固,且瘢痕形成最小或无瘢痕形成。给出了理想激光以有效且选择性方式凝固鲜红斑痣的两个简单物理要求,建议应用发射波长为418纳米或577纳米的脉冲染料激光。

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