在由进食到饥饿的转变过程中以及急性或长期饥饿后再进食时的丙酮酸脱氢酶活性。
Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.
作者信息
Holness M J, Sugden M C
机构信息
Department of Chemical Pathology, London Hospital Medical College, U.K.
出版信息
Biochem J. 1989 Mar 1;258(2):529-33. doi: 10.1042/bj2580529.
Abstract
We investigated the temporal relationship between hepatic glycogen depletion and cardiac and hepatic PDH (pyruvate dehydrogenase complex) activities during the acute phase of starvation. There was a striking correlation between the decline in hepatic glycogen and PDH inactivation during the first 10 h of starvation. Re-feeding after 6 h starvation was associated with complete re-activation of PDH in liver and re-activation to approx. 75% of the fed value in heart, whereas in rats previously starved for 24-48 h re-activation was delayed in liver and diminished in heart. The results are discussed with reference to the fate of dietary carbohydrate after re-feeding.
摘要
我们研究了饥饿急性期肝糖原消耗与心脏和肝脏丙酮酸脱氢酶复合体（PDH）活性之间的时间关系。在饥饿的前10小时内，肝糖原下降与PDH失活之间存在显著相关性。饥饿6小时后重新喂食与肝脏中PDH的完全重新激活以及心脏中重新激活至喂食状态值的约75%相关，而在先前饥饿24 - 48小时的大鼠中，肝脏中的重新激活延迟，心脏中的重新激活减弱。结合重新喂食后膳食碳水化合物的去向对结果进行了讨论。
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本文引用的文献
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