Holness M J, Sugden M C
Department of Biochemistry, London Hospital Medical College, U.K.
Biochem J. 1989 Aug 15;262(1):321-5. doi: 10.1042/bj2620321.
Meal-fed rats and rats fed ad libitum had similar rates of hepatic glycogenesis at 60 min after the initiation of re-feeding a chow meal after 22 h starvation, but hepatic PDHa (active form of pyruvate dehydrogenase) activities were 4-fold higher in the meal-fed group. In heart, PDHa activities were 3-fold higher before re-feeding and 2-fold higher after re-feeding in the meal-fed group compared with the group fed ad lib. The blood metabolite profile suggested diminished fat oxidation in starved meal-fed rats and accelerated flux through PDH in meal-fed re-fed rats compared with the group fed ad lib.
在饥饿22小时后重新喂食普通饲料60分钟时，定时喂食的大鼠和自由采食的大鼠肝脏糖原生成速率相似，但定时喂食组的肝脏丙酮酸脱氢酶（PDH，丙酮酸脱氢酶的活性形式）活性高4倍。在心脏中，与自由采食组相比，定时喂食组在重新喂食前PDH活性高3倍，重新喂食后高2倍。血液代谢物谱表明，与自由采食组相比，饥饿后定时喂食的大鼠脂肪氧化减少，重新喂食后定时喂食的大鼠通过PDH的通量加快。
