Battal Fatih, Tekin Mustafa, Aylanç Hakan, Yıldırım Şule, Türkön Hakan, Binnetoğlu Fatih Köksal, Kaymaz Nazan, Topaloğlu Naci
Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Faculty of Medicine, Department of Biochemistry, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Int J Adolesc Med Health. 2016 Apr 9;30(1):/j/ijamh.2018.30.issue-1/ijamh-2015-0128/ijamh-2015-0128.xml. doi: 10.1515/ijamh-2015-0128.
It is known that the biochemical marker linked to tissue ischemia, ischemia-modified albumin (IMA), is related to oxidative stress. Cigarette smoking is a situation with increased oxidative stress causing cell damage and it is thought that many of the negative effects linked to smoking may occur after the biological material in the body is exposed to oxidative damage. This study aimed to identify variability in serum IMA levels in adolescents who smoke.
This case-control study comprised 60 adolescents without any chronic disease. The smoking group was 30 adolescents between the ages of 14 and 17 years who smoked, while the control group was 30 healthy adolescents who did not smoke. Blood samples were collected from all subjects and serum IMA levels and serum nicotine metabolites were determined.
The serum IMA levels in the adolescents who smoked were 0.452±0.094 absorbance unit (ABSU), while the control group had ASBU levels of 0.427±0.054. There was no significant difference between the groups in terms of serum IMA levels (p=0.210). There was a significant difference between the control and smoking groups in terms of serum nicotine metabolite levels (p<0.001).
Among adolescents who smoke, serum IMA levels may not be a good marker for oxidative stress.
