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给予半胱氨酸缺乏饮食的大鼠肝脏中谷胱甘肽状态及3,5,3'-三碘甲状腺原氨酸作用的变化

Changes in glutathione status and 3,5,3'-triiodothyronine action in livers of rats given cysteine-deficient diets.

作者信息

Garcin H, Suberville C, Higueret P, Higueret D

机构信息

Département Alimentation et Nutrition, Université de Bordeaux I, Talence, France.

出版信息

Br J Nutr. 1989 Mar;61(2):301-7. doi: 10.1079/bjn19890118.

DOI:10.1079/bjn19890118
PMID:2706229
Abstract
  1. For a period of 32 d young rats were given a diet containing (g/kg) 220 casein, 120 casein + 1.93 L-cysteine (Cys), or 120 casein. 2. The formation of 3,5,3'-triiodothyronine (T3)-nuclear protein complexes was reduced in rats fed on the Cys-deficient diet. 3. Scatchard analysis showed that decreased formation of T3-nuclear protein complexes was due to a decreased affinity of T3 receptors; this decrease was induced, at least in part, by a reduced glutathione content. 4. In rats fed on the Cys-deficient diet there was an expected decrease in growth but an unexpected increase in the activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40). It is suggested that this increase is related to an increased oxidized glutathione:reduced glutathione ratio.
摘要
  1. 在32天的时间里,给幼鼠喂食含有(克/千克)220酪蛋白、120酪蛋白 + 1.93 L-半胱氨酸(Cys)或120酪蛋白的日粮。2. 喂食半胱氨酸缺乏日粮的大鼠中,3,5,3'-三碘甲状腺原氨酸(T3)-核蛋白复合物的形成减少。3. 斯卡查德分析表明,T3-核蛋白复合物形成减少是由于T3受体亲和力降低;这种降低至少部分是由谷胱甘肽含量减少引起的。4. 在喂食半胱氨酸缺乏日粮的大鼠中,生长如预期下降,但葡萄糖-6-磷酸脱氢酶(EC 1.1.1.49)和苹果酸脱氢酶(草酰乙酸脱羧)(NADP+)(EC 1.1.1.40)的活性意外增加。有人认为这种增加与氧化型谷胱甘肽:还原型谷胱甘肽比率增加有关。

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