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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Suberville C, Higueret P, Taruoura D, Garcin H, Higueret D

Département Alimentation et Nutrition, Université de Bordeaux I, Talence, France.

Br J Nutr. 1988 May;59(3):451-6. doi: 10.1079/bjn19880054.

For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1.93 g cysteine/kg. 2. The thyroxine (T4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T4 pool and T4 disposal rate decreased. 3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T3). The T3 distribution space, extrathyroidal pool of T3 and T3 disposal rate were diminished. 4. In vitro, deiodination of T4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet.

在24天的时间里，幼鼠食用含有120克酪蛋白/千克的饲料，或食用添加了1.93克半胱氨酸/千克的相同基础饲料。2. 与食用补充饲料的大鼠相比，食用缺乏半胱氨酸饲料的大鼠甲状腺素（T4）周转率降低。此外，甲状腺外T4池和T4处置率降低。3. 半胱氨酸缺乏也会降低3,5,3'-三碘甲状腺原氨酸（T3）的外周代谢。T3分布空间、甲状腺外T3池和T3处置率均降低。4. 在体外，用内源性谷胱甘肽（GSH）测定肝匀浆中T4的脱碘作用，结果表明在半胱氨酸缺乏的情况下T3生成率降低。通过添加足以使反应动力学饱和的GSH量，这种差异最小化。鉴于这一发现，GSH可能参与了由缺乏半胱氨酸的饮食引起的某些甲状腺问题。

Suberville C, Higueret P, Taruoura D, Garcin H, Higueret D

Département Alimentation et Nutrition, Université de Bordeaux I, Talence, France.

Br J Nutr. 1988 May;59(3):451-6. doi: 10.1079/bjn19880054.

For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1.93 g cysteine/kg. 2. The thyroxine (T4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T4 pool and T4 disposal rate decreased. 3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T3). The T3 distribution space, extrathyroidal pool of T3 and T3 disposal rate were diminished. 4. In vitro, deiodination of T4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet.

在24天的时间里，幼鼠食用含有120克酪蛋白/千克的饲料，或食用添加了1.93克半胱氨酸/千克的相同基础饲料。2. 与食用补充饲料的大鼠相比，食用缺乏半胱氨酸饲料的大鼠甲状腺素（T4）周转率降低。此外，甲状腺外T4池和T4处置率降低。3. 半胱氨酸缺乏也会降低3,5,3'-三碘甲状腺原氨酸（T3）的外周代谢。T3分布空间、甲状腺外T3池和T3处置率均降低。4. 在体外，用内源性谷胱甘肽（GSH）测定肝匀浆中T4的脱碘作用，结果表明在半胱氨酸缺乏的情况下T3生成率降低。通过添加足以使反应动力学饱和的GSH量，这种差异最小化。鉴于这一发现，GSH可能参与了由缺乏半胱氨酸的饮食引起的某些甲状腺问题。