治疗前中性粒细胞与淋巴细胞计数比值可能与胃癌的存在有关。

Pretreatment neutrophil-lymphocyte count ratio may associate with gastric cancer presence.

作者信息

Jiang Yuanyuan, Xu Huan, Jiang Hongmin, Ding Siyi, Zheng Taiqing

机构信息

Department of Clinical Laboratory, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Department of Clinical Laboratory, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

出版信息

Cancer Biomark. 2016 Mar 4;16(4):523-8. doi: 10.3233/CBM-160593.

DOI:10.3233/CBM-160593

PMID:27062567

Abstract

BACKGROUND

Inflammation plays a pivotal role in cancer development and progression. Neutrophil-lymphocyte count ratio (NLR) is an indicator of systemic inflammatory response which is supposedly associated with gastric cancer (GC) development and progression. Since this parameter can be easily obtained from routine blood examination, it will be a great economic relief to gastric patients if we can bring it into clinical application.

OBJECTIVE

The current study aims to evaluate the pretreatment NLR in gastric cancer patients through retrospectively reviewing the medical records.

METHODS

A total of 327 patients hospitalized on a tertiary care hospital were retrospectively investigated and divided into two groups. Gastric cancer group were composed of patients with newly diagnosed, pathologically confirmed GC and the control group were patients with gastric polyp or benign gastric stromal tumor. The value of NLR in the presence and stage of gastric cancer was investigated in the entire gastric cancer group.

RESULTS

Our study showed levels of NLR were significantly higher in gastric cancer cohort (2.17 (1.63-3.09) versus 1.62 (0.85-2.32), p< 0.001). After all the known confounders were excluded, NLR was an independent predicator of GC (OR = 1.446, 95%CI (1.121-1.866), and P= 0.005). Area under ROC curve (AUC) of NLR was 0.694. In addition, the results of Spearman's correlation showed NLR may have a positive correlation with size of tumor, N-stage, distant metastasis, and overall stage (r = 0.256, 0.256, 0.161 and 0.171, resp., all p < 0.05).

CONCLUSIONS

The current study demonstrated that pre-treatment NLR may be a useful biomarker in the health care of gastric cancer patients.

摘要

背景

炎症在癌症的发生和发展中起着关键作用。中性粒细胞与淋巴细胞计数比值（NLR）是全身炎症反应的一个指标，据推测与胃癌（GC）的发生和发展有关。由于该参数可从常规血液检查中轻松获得，如果能将其应用于临床，将极大地减轻胃癌患者的经济负担。

目的

本研究旨在通过回顾病历，评估胃癌患者的治疗前NLR。

方法

回顾性调查了一家三级医院收治的327例患者，并将其分为两组。胃癌组由新诊断、病理确诊的GC患者组成，对照组为胃息肉或良性胃间质瘤患者。在整个胃癌组中研究了NLR在胃癌存在和分期中的价值。

结果

我们的研究表明，胃癌队列中的NLR水平显著更高（2.17（1.63 - 3.09）对1.62（0.85 - 2.32），p < 0.001）。在排除所有已知混杂因素后，NLR是GC的独立预测因子（OR = 1.446，95%CI（1.121 - 1.866），P = 0.005）。NLR的ROC曲线下面积（AUC）为0.694。此外，Spearman相关性结果显示，NLR可能与肿瘤大小、N分期、远处转移和总分期呈正相关（r分别为0.256、0.256、0.161和0.171，均p < 0.05）。