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心力衰竭与心血管衰老中的肾上腺素能信号传导。

Adrenergic signaling in heart failure and cardiovascular aging.

作者信息

Santulli Gaetano, Iaccarino Guido

机构信息

College of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA.

Division of Internal Medicine, Department of Medicine and Surgery, University of Salerno, Italy.

出版信息

Maturitas. 2016 Nov;93:65-72. doi: 10.1016/j.maturitas.2016.03.022. Epub 2016 Mar 26.

DOI:10.1016/j.maturitas.2016.03.022
PMID:27062709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5036981/
Abstract

Both cardiovascular disease and aging are associated with changes in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disorders, in particular heart failure. This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging.

摘要

心血管疾病和衰老都与交感神经系统的变化有关。事实上,越来越多的证据表明,肾上腺素能受体在衰老和心血管疾病(尤其是心力衰竭)的众多潜在过程中发挥着功能作用。本文将综述交感神经系统在心力衰竭和心血管衰老中的病理生理作用。

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本文引用的文献

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Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.
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The possible role of chromosome X variability in hypertensive familiarity.X染色体变异性在高血压家族性中的可能作用。
J Hum Hypertens. 2017 Jan;31(1):37-42. doi: 10.1038/jhh.2016.9. Epub 2016 Feb 25.
3
Healthy aging and myocardium: A complicated process with various effects in cardiac structure and physiology.健康衰老与心肌:一个在心脏结构和生理方面具有多种影响的复杂过程。
Int J Cardiol. 2016 Apr 15;209:167-75. doi: 10.1016/j.ijcard.2016.02.039. Epub 2016 Feb 4.
4
Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study.心力衰竭患者心肌局部间质纤维化与左心室内不同步相关:一项心血管磁共振研究
Sci Rep. 2016 Feb 5;6:20711. doi: 10.1038/srep20711.
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Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart.间充质干细胞衍生的炎性成纤维细胞介导衰老心脏中的间质纤维化。
J Mol Cell Cardiol. 2016 Feb;91:28-34. doi: 10.1016/j.yjmcc.2015.12.017. Epub 2015 Dec 22.
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J Am Heart Assoc. 2015 Dec 18;4(12):e002613. doi: 10.1161/JAHA.115.002613.
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microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis.微小RNA对血管平滑肌细胞和内皮细胞具有独特调控作用:对血管生成、动脉粥样硬化及支架内再狭窄的功能影响
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