功能失调的线粒体导致老年心脏生物能量下降。

Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.

作者信息

Mone Pasquale, Agyapong Esther Densu, Morciano Giampaolo, Jankauskas Stanislovas S, De Luca Antonio, Varzideh Fahimeh, Pinton Paolo, Santulli Gaetano

机构信息

Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.

Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy.

出版信息

J Cardiovasc Aging. 2024 Apr;4(2). doi: 10.20517/jca.2023.50. Epub 2024 Feb 1.

DOI:10.20517/jca.2023.50

PMID:39015481

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250775/

Abstract

Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.

摘要

衰老代表着一个影响全身的复杂生物学进程，其特征是组织功能逐渐衰退，使器官更容易受到压力和疾病的影响。在这种情况下，人类心脏至关重要，因为其衰老过程会带来危及生命的风险。它涉及宏观形态变化和生化改变，这些共同导致心脏功能下降。在线粒体众多关键因素中，线粒体起着关键作用，它与各种分子途径相互作用，并包含多种与衰老相关的因子。在这篇全面综述中，我们提供了线粒体在心脏衰老中功能作用的最新概述。